Do you feel pain in zero gravity?

Zero gravity itself doesn't cause pain, but adaptation can be uncomfortable. Initial symptoms of space adaptation syndrome (space sickness) include nausea, headaches, and disorientation, affecting 40-50% of astronauts initially. Fluid redistribution causes facial puffiness and congestion ("puffy face syndrome"). Long-term effects include bone demineralization and muscle atrophy, which can cause discomfort. Existing injuries might feel different without gravity pulling on them. Most astronauts adapt within a few days and find weightlessness comfortable and enjoyable.