A genetic cross involves a true-breeding plant with red flowers (RR) and a true-breeding plant with white flowers (rr). If red is dominant over white, what is the probability of obtaining white-flowered plants in the F2 generation?

First, the cross between RR and rr will produce an F1 generation that is entirely Rr (red flowers). When two F1 plants (Rr x Rr) are crossed, the F2 generation will have genotypes RR, Rr, and rr in a 1:2:1 ratio. The phenotypes will be 3 red (RR, Rr) : 1 white (rr). Therefore, the probability of obtaining white-flowered plants in the F2 generation is 1/4 or 25%.